Loss of bone density, if Lupron Depot is taken long term. Convulsions (violent shaking, seizures). Problems with your heart’s electrical activity, such as long QT syndrome .Jul 15, 2023 · Warning: Blood Pressure IncreasesTestosterone undecanoate can cause blood pressure (BP) increases that can increase the risk of major adverse cardiovascular events (MACE), including non-fatal myocardial infarction, non-fatal stroke and cardiovascular death. The most commonly reported side effects were hot flashes or sweats, gastrointestinal disorders, hyperhidrosis, edema, emotional lability or depression, respiratory disorder, urinary disorder, nausea or vomiting, injection site reaction, joint disorders, testicular atrophy, asthenia, flu syndrome, headache, skin reaction, fatigue, and pain.Lifestyle Changes. Depo-Provera ( depot medroxyprogesterone acetate , or DMPA) is an effective and relatively easy form of birth control. It does appear to cause weight gain for many women, though. Weight gain is often cited as the reason women stop using the shots. DMPA can change body composition and increase fat mass.A further benefit of depot treatment is the achievement of stable plasma concentrations over long periods, allowing injections to be given every few weeks. However, this also represents a potential disadvantage in that there is a lack of flexibility of administration. Should adverse effects develop, the drug cannot be rapidly withdrawn. Warning: Blood Pressure IncreasesTestosterone undecanoate can cause blood pressure (BP) increases that can increase the risk of major adverse cardiovascular events (MACE), including non-fatal myocardial infarction, non-fatal stroke and cardiovascular death.Jan 11, 2023 · Appropriate Use. The Depo-Provera birth control shot has advantages and disadvantages compared to other types of birth control. While it's convenient and effective, for example, the Depo shot also carries the risk of side effects like irregular bleeding and bone loss. This article looks at some of the pros and cons of using Depo-Provera. Good advice below - re: leaving your ovaries in! I had my one and only grand mal seizure on the day I got my period back - about 6 months after taking my last Depo Provera shot. I only took 2 injections of the drug but stopped it due to concerns about loss of bone density and the strange periods that I was having.Jun 14, 2023 · DEPO-MEDROL is an anti-inflammatory glucocorticoid for intramuscular, intra-articular, soft tissue, or intralesional injection. It is available in three strengths: 20 mg/mL, 40 mg/mL, 80 mg/mL. Sodium Chloride was added to adjust tonicity. When necessary, pH was adjusted with sodium hydroxide and/or hydrochloric acid. Jan 2, 2023 · The most commonly reported side effects were hot flashes or sweats, gastrointestinal disorders, hyperhidrosis, edema, emotional lability or depression, respiratory disorder, urinary disorder, nausea or vomiting, injection site reaction, joint disorders, testicular atrophy, asthenia, flu syndrome, headache, skin reaction, fatigue, and pain. Hot flashes (flushing), increased sweating, night sweats, tiredness, headache, upset stomach, breast changes, acne, joint/muscle aches, trouble sleeping, reduced sexual interest, vaginal ...Jan 6, 2022 · Allergy shots are a form of treatment called immunotherapy. Each allergy shot contains a tiny amount of the specific substance or substances that trigger your allergic reactions. These are called allergens. Allergy shots contain just enough allergens to stimulate your immune system — but not enough to cause a full-blown allergic reaction. A further benefit of depot treatment is the achievement of stable plasma concentrations over long periods, allowing injections to be given every few weeks. However, this also represents a potential disadvantage in that there is a lack of flexibility of administration. Should adverse effects develop, the drug cannot be rapidly withdrawn.In many cases, unwanted effects of the Mirena IUD are not long-term. According to Planned Parenthood, common side effects such as spotting between periods and cramping typically get better in 3 ...Mar 23, 2022 · Other long-term birth control options include the: ... The Depo-Provera shot needs to be administered every three months. The birth control implant works for three years. ... Side effects usually ... Satisfaction. I'm a 40 yr. old that has been taking Depo-Provera for about 11 years. I like it all except, that I have to go to the doctor every 3 months and I do have the shakes and anxiety, heart palpitations, etc. BUT I also had anxiety before so not exactly sure if the shot is causing it. Also I do feel tired alot.Dec 14, 2001 · Campbell complains about serious side effects from Depo-Provera herself, so those attracted to her survey undoubtedly tend to have worries about the drug. The number one complaint was weight gain ... Examples include birth control pills, as well as the vaginal ring (NuvaRing), skin patch (Xulane) and contraceptive injection (Depo-Provera). These are considered short-acting methods because you have to remember to use them on a daily, weekly or monthly basis. Long-acting hormonal methods.Forty-three subjects (37% of discontinuers) restarted Depo-Provera during the study period, with a mean time to restart of 8.4 months after the last Depo-Provera injection. Side effects were the main reported reason for Depo-Provera discontinuation, primarily menstrual irregularities (26%) and weight gain (18%). SU. suzanne66 7 March 2010. Chemical castration (as it is referred to in males) by using Depo-provera lowers testosterone and reduces sex drive. Males can have sexual intercourse but do not want to. It also discourages sexual fantasies and eradicates sexual obsessions. Mood changes and depression are reported side-effects of depo-provera.Summary. Commonly reported side effects of paliperidone include: akathisia, tachycardia, and drowsiness. Other side effects include: basal ganglia disease, dyskinesia, dystonia, orthostatic hypotension, postencephalitic parkinson's disease, sialorrhea, and prolonged qt interval on ecg. Continue reading for a comprehensive list of adverse effects.SU. suzanne66 7 March 2010. Chemical castration (as it is referred to in males) by using Depo-provera lowers testosterone and reduces sex drive. Males can have sexual intercourse but do not want to. It also discourages sexual fantasies and eradicates sexual obsessions. Mood changes and depression are reported side-effects of depo-provera.One major drawback of Depo-Provera is the continuous or irregular bleeding (spotting) that can sometimes occur during the first year. While this typically occurs during the first few months, it can persist for up to a year or longer for some people. Learn more about this side effect and what you can do if it persists. TEK IMAGE / Getty Images.Long-term case-controlled surveillance of users of Depo-Provera CI found no overall increased risk of ovarian or liver cancer. 5.4 Ectopic Pregnancy Be alert to the possibility of an ectopic pregnancy among women using Depo-Provera CI who become pregnant or complain of severe abdominal pain.Effects on baby A small amount of the synthetic hormones in contraceptives will enter your milk, there is no evidence that this is dangerous to your baby. Some babies younger than six weeks may have difficulty metabolising the hormones and for this reason it is not recommended to start using a hormonal contraceptive until your baby is older. The most common side effects associated with DMPA use are bothersome but benign and typically improve with time or upon discontinuation, including irregular bleeding, weight gain, dizziness, abdominal pain, and anxiety . Occasionally, other side effects do occur and may cause significant distress to the patient.A further benefit of depot treatment is the achievement of stable plasma concentrations over long periods, allowing injections to be given every few weeks. However, this also represents a potential disadvantage in that there is a lack of flexibility of administration. Should adverse effects develop, the drug cannot be rapidly withdrawn. pain, tenderness, or swelling of the foot or leg. puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue. severe, sudden headache. shortness of breath. slurred speech. stopping of menstrual bleeding. sudden loss of coordination. sudden, severe weakness or numbness in the arm or leg.Long-term effects of injection Depo-Provera (depo-medroxyprogesterone acetate) on carbohydrate and lipid metabolism were studied in 157 women who were treated continuously for a mean duration of 43.3 months. The patients were matched with 162 controls for race, age, parity and height. Glucose tolerance was impaired with higher intolerance at ...Common side effects may include: weight gain (especially in your face or your upper back and torso); slow wound healing; muscle pain or weakness; thinning skin, increased sweating; stomach ...DEPO-MEDROL is an anti-inflammatory glucocorticoid for intramuscular, intra-articular, soft tissue, or intralesional injection. It is available in three strengths: 20 mg/mL, 40 mg/mL, 80 mg/mL. Sodium Chloride was added to adjust tonicity. When necessary, pH was adjusted with sodium hydroxide and/or hydrochloric acid.Aug 9, 2023 · Depo-Provera use may also delay the return of your fertility. About 50% of women will be able to get pregnant within 10 months after their last Depo-Provera injection, but it can take up to 18 months for fertility to return. Some women report irregular or continuous bleeding when using Depo-Provera along with other unwanted side effects. PIP: In Chiang Mai, Thailand, community physicians followed 2422 women who used the contraceptive injectable, Depo-Provera (DMPA), either during pregnancy and/or while breast feeding. They compared the longterm growth of the children exposed to DMPA with that of 1167 children who were not exposed to hormones during pregnancy or lactation.Purpose and method: Our objective is to evaluate the effects of the long-term use of depot medroxyprogesterone acetate (DMPA) as a method of contraception on bone mineral density (BMD) and bone remodeling. Forty women (21-44 years old) who used DMPA for contraception for <1, 1-2 and >5 years, in addition to 20 age-matched healthy women ...Mar 5, 2023 · Very common (10% or more): Increase weight (up to 37%) Common (1% to 10%): Increased appetite, decreased appetite. Uncommon (0.1% to 1%): Diabetes mellitus exacerbated, hypercalcemia, fluid retention. Frequency not reported: Elevations of serum calcium and potassium levels, exacerbation of diabetes mellitus. Jan 15, 2022 · itchiness. flushing (warmth and redness or deepening of color in your skin) A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include: swelling under ... Apr 25, 2023 · When To See a Healthcare Provider. Signs of pregnancy after Depo-Provera ( medroxyprogesterone ) may include missed period, nausea, breast tenderness, and more. Many people are able to get pregnant around 8 to 10 months after their last Depo-Provera shot. Depo-Provera, an injectable birth control method, is more than 99% effective at preventing ... Appropriate Use. The Depo-Provera birth control shot has advantages and disadvantages compared to other types of birth control. While it's convenient and effective, for example, the Depo shot also carries the risk of side effects like irregular bleeding and bone loss. This article looks at some of the pros and cons of using Depo-Provera.After my very first injection 22 years ago, I have had zero periods and zero breakthrough bleeding. Zero side effects. Nothing. This has been a blessing. I had my last Depo Shot on 1/12/21. My next one is not due until 3/30/21. Today I wake up and have bleeding. Apr 25, 2023 · When To See a Healthcare Provider. Signs of pregnancy after Depo-Provera ( medroxyprogesterone ) may include missed period, nausea, breast tenderness, and more. Many people are able to get pregnant around 8 to 10 months after their last Depo-Provera shot. Depo-Provera, an injectable birth control method, is more than 99% effective at preventing ... Aug 9, 2023 · Depo-Provera use may also delay the return of your fertility. About 50% of women will be able to get pregnant within 10 months after their last Depo-Provera injection, but it can take up to 18 months for fertility to return. Some women report irregular or continuous bleeding when using Depo-Provera along with other unwanted side effects. Aug 7, 2023 · signs of a blood clot - sudden numbness or weakness, severe headache, chest pain, sudden cough, coughing up blood; problems with vision or speech, swelling or pain in an arm or leg. Common Depo-Provera side effects may include: changes in your menstrual periods; weakness, feeling tired; stomach pain; feeling nervous; Spotting (light bleeding or brown discharge between periods) Not getting your period at all. About half of people stop getting their period while they’re on the shot (don’t worry, this is totally safe). Other possible side effects include: Nausea. Weight gain. Headaches. Sore breasts. Depression. Aug 28, 2023 · Common side effects of Depo-Estradiol may include: breast pain; headache; vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding; thinning scalp hair; or. nausea, vomiting, bloating, stomach cramps. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side ... Long-term case-controlled surveillance of users of Depo-Provera CI found no overall increased risk of ovarian or liver cancer. 5.4 Ectopic Pregnancy Be alert to the possibility of an ectopic pregnancy among women using Depo-Provera CI who become pregnant or complain of severe abdominal pain.Spotting (light bleeding or brown discharge between periods) Not getting your period at all. About half of people stop getting their period while they’re on the shot (don’t worry, this is totally safe). Other possible side effects include: Nausea. Weight gain. Headaches. Sore breasts. Depression.A depot injection is a slow-release form of medication. The injection uses a liquid that releases the medication slowly, so it lasts a lot longer. Depot injections can be used for various types of drug, including some antipsychotics. The medication used in depot injections is the same as other forms of the drug, such as tablets or liquid.Long-term side effects Some diseases and medical conditions require long-term treatment with corticosteroids, at either an anti-inflammatory dose or an immunosuppressive dose. When corticosteroids will be used for more than three to four months, particularly at immunosuppressive doses, additional side effects become a concern. Depo-Medrol Side Effects: Common, Severe, Long Term Home Depo-Medrol Side Effects Print Save Depo-Medrol Side Effects Generic name: methylprednisolone Medically reviewed by Drugs.com. Last updated on Dec 7, 2022. Serious side effects Other side effects Professional info FAQslurred speech. stopping of menstrual bleeding. sudden loss of coordination. sudden, severe weakness or numbness in the arm or leg. sudden, unexplained shortness of breath. swelling of the fingers, hands, feet, or lower legs. troubled breathing at rest. unexpected or excess milk flow from the breasts.Nov 12, 2020 · This article highlights medroxyprogesterone as it is used as contraception to prevent pregnancy. This activity discusses the mechanism of action, adverse effects, monitoring, and contraindications for medroxyprogesterone. Also, it highlights the important role that providers play in administering medroxyprogesterone and regularly monitoring patients for side effects. Aug 15, 2019 · Objectives Depo-Provera is an injectable contraceptive method containing medroxyprogesterone acetate. It has some adverse effects like changes in menstrual pattern, loss in bone mineral density and risk of weight gain. Therefore, this study is aimed at to investigate the effects of Depo-Provera on body weight and blood pressure among Ethiopian women. Institution based cross-sectional study ... So I have been on depo for about two years now and have never had severe problems. I have noticed since starting Depo that I have more vaginal discharge, more acne, and my boobs tend to be sore more often. However, this past week I have noticed an intense increase in some side effects. My boobs are extremely sore and I am having a mixture of ...Appropriate Use. The Depo-Provera birth control shot has advantages and disadvantages compared to other types of birth control. While it's convenient and effective, for example, the Depo shot also carries the risk of side effects like irregular bleeding and bone loss. This article looks at some of the pros and cons of using Depo-Provera.slurred speech. stopping of menstrual bleeding. sudden loss of coordination. sudden, severe weakness or numbness in the arm or leg. sudden, unexplained shortness of breath. swelling of the fingers, hands, feet, or lower legs. troubled breathing at rest. unexpected or excess milk flow from the breasts.Jan 31, 2017 · Here are a few potential side effects to be aware of if you use it. 1. You might stop having periods. The most common side effect of the shot is a change in a woman’s bleeding pattern, Jason ... In fact, women frequently discontinue hormonal contraception because of irregular bleeding and other side effects. 1 – 3 One study 4 found that 32 percent of 1,657 women who started taking oral ...Good advice below - re: leaving your ovaries in! I had my one and only grand mal seizure on the day I got my period back - about 6 months after taking my last Depo Provera shot. I only took 2 injections of the drug but stopped it due to concerns about loss of bone density and the strange periods that I was having. Hot flashes (flushing), increased sweating, night sweats, tiredness, headache, upset stomach, breast changes, acne, joint/muscle aches, trouble sleeping, reduced sexual interest, vaginal ...Warning: Blood Pressure IncreasesTestosterone undecanoate can cause blood pressure (BP) increases that can increase the risk of major adverse cardiovascular events (MACE), including non-fatal myocardial infarction, non-fatal stroke and cardiovascular death.The most common side effects associated with DMPA use are bothersome but benign and typically improve with time or upon discontinuation, including irregular bleeding, weight gain, dizziness, abdominal pain, and anxiety . Occasionally, other side effects do occur and may cause significant distress to the patient.Good advice below - re: leaving your ovaries in! I had my one and only grand mal seizure on the day I got my period back - about 6 months after taking my last Depo Provera shot. I only took 2 injections of the drug but stopped it due to concerns about loss of bone density and the strange periods that I was having.May 15, 2002 · In fact, women frequently discontinue hormonal contraception because of irregular bleeding and other side effects. 1 – 3 One study 4 found that 32 percent of 1,657 women who started taking oral ... Warning: Blood Pressure IncreasesTestosterone undecanoate can cause blood pressure (BP) increases that can increase the risk of major adverse cardiovascular events (MACE), including non-fatal myocardial infarction, non-fatal stroke and cardiovascular death.So I have been on depo for about two years now and have never had severe problems. I have noticed since starting Depo that I have more vaginal discharge, more acne, and my boobs tend to be sore more often. However, this past week I have noticed an intense increase in some side effects. My boobs are extremely sore and I am having a mixture of ...A further benefit of depot treatment is the achievement of stable plasma concentrations over long periods, allowing injections to be given every few weeks. However, this also represents a potential disadvantage in that there is a lack of flexibility of administration. Should adverse effects develop, the drug cannot be rapidly withdrawn. Common side effects of Depo-Estradiol may include: breast pain; headache; vaginal itching or discharge, changes in your menstrual periods, breakthrough bleeding; thinning scalp hair; or. nausea, vomiting, bloating, stomach cramps. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side ...Campbell complains about serious side effects from Depo-Provera herself, so those attracted to her survey undoubtedly tend to have worries about the drug. The number one complaint was weight gain ...Jul 15, 2023 · Warning: Blood Pressure IncreasesTestosterone undecanoate can cause blood pressure (BP) increases that can increase the risk of major adverse cardiovascular events (MACE), including non-fatal myocardial infarction, non-fatal stroke and cardiovascular death. The most commonly reported side effects were hot flashes or sweats, gastrointestinal disorders, hyperhidrosis, edema, emotional lability or depression, respiratory disorder, urinary disorder, nausea or vomiting, injection site reaction, joint disorders, testicular atrophy, asthenia, flu syndrome, headache, skin reaction, fatigue, and pain.Aug 9, 2023 · Depo-Provera use may also delay the return of your fertility. About 50% of women will be able to get pregnant within 10 months after their last Depo-Provera injection, but it can take up to 18 months for fertility to return. Some women report irregular or continuous bleeding when using Depo-Provera along with other unwanted side effects. The most commonly reported side effects were hot flashes or sweats, gastrointestinal disorders, hyperhidrosis, edema, emotional lability or depression, respiratory disorder, urinary disorder, nausea or vomiting, injection site reaction, joint disorders, testicular atrophy, asthenia, flu syndrome, headache, skin reaction, fatigue, and pain.Mar 6, 2023 · Lupron is a drug doctors prescribe to treat prostate cancer. It works by reducing testosterone levels in the body, slowing cancer growth. Lupron is the brand name for leuprolide acetate. Lupron ... Sep 28, 2021 · One major drawback of Depo-Provera is the continuous or irregular bleeding (spotting) that can sometimes occur during the first year. While this typically occurs during the first few months, it can persist for up to a year or longer for some people. Learn more about this side effect and what you can do if it persists. TEK IMAGE / Getty Images. Short-term side effects. Short-term side effects are those that we expect a cat to experience when initially placed on corticosteroids. These side effects depend both on the type of steroid prescribed and on the dosage administered and include: increased thirst and urination. increased hunger. general loss of energy.slurred speech. stopping of menstrual bleeding. sudden loss of coordination. sudden, severe weakness or numbness in the arm or leg. sudden, unexplained shortness of breath. swelling of the fingers, hands, feet, or lower legs. troubled breathing at rest. unexpected or excess milk flow from the breasts.some people may put on weight when they use Depo-Provera or Sayana Press contraceptive injections; you may experience side effects like headaches, acne, hair loss, decreased sex drive and mood swings; any side effects can continue for as long as the injection lasts (8 or 13 weeks) and for some time after; RisksAfter my very first injection 22 years ago, I have had zero periods and zero breakthrough bleeding. Zero side effects. Nothing. This has been a blessing. I had my last Depo Shot on 1/12/21. My next one is not due until 3/30/21. Today I wake up and have bleeding.Depo-Provera Contraceptive Injection should not be used as a long-term birth control method (i.e., longer than 2 years) unless other birth control methods are considered inadequate. (See Warnings and Precautions (5.1)). 1 INDICATIONS AND USAGE Depo-Provera CI is indicated only for the prevention of pregnancy. The loss of bone mineral densityApr 25, 2023 · When To See a Healthcare Provider. Signs of pregnancy after Depo-Provera ( medroxyprogesterone ) may include missed period, nausea, breast tenderness, and more. Many people are able to get pregnant around 8 to 10 months after their last Depo-Provera shot. Depo-Provera, an injectable birth control method, is more than 99% effective at preventing ... PIP: In Chiang Mai, Thailand, community physicians followed 2422 women who used the contraceptive injectable, Depo-Provera (DMPA), either during pregnancy and/or while breast feeding. They compared the longterm growth of the children exposed to DMPA with that of 1167 children who were not exposed to hormones during pregnancy or lactation. For most people, being on birth control long term is safe. Birth control can lower your risk for some cancers and raise your risk for others. It can cause blood clots, heart attacks, and strokes — but the risks are small. Being on birth control doesn’t make it harder to become pregnant once you stop it. 02:48.Jan 2, 2023 · The most commonly reported side effects were hot flashes or sweats, gastrointestinal disorders, hyperhidrosis, edema, emotional lability or depression, respiratory disorder, urinary disorder, nausea or vomiting, injection site reaction, joint disorders, testicular atrophy, asthenia, flu syndrome, headache, skin reaction, fatigue, and pain. Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight. Depression or other mood changes. Eyesight changes or loss, bulging eyes, or change in how contact lenses feel. A lump in the breast, breast pain or soreness, or nipple discharge. Flu -like signs.
Jan 2, 2023 · The most commonly reported side effects were hot flashes or sweats, gastrointestinal disorders, hyperhidrosis, edema, emotional lability or depression, respiratory disorder, urinary disorder, nausea or vomiting, injection site reaction, joint disorders, testicular atrophy, asthenia, flu syndrome, headache, skin reaction, fatigue, and pain. . Wheeling nippon steel
altered interest in having sexual intercourse. abnormal bleeding from the uterus. a problem with menstrual periods. dizziness. weight gain. headache. nervousness. reactions at the site of the ...some people may put on weight when they use Depo-Provera or Sayana Press contraceptive injections; you may experience side effects like headaches, acne, hair loss, decreased sex drive and mood swings; any side effects can continue for as long as the injection lasts (8 or 13 weeks) and for some time after; Risks Oct 1, 2022 · Lifestyle Changes. Depo-Provera ( depot medroxyprogesterone acetate , or DMPA) is an effective and relatively easy form of birth control. It does appear to cause weight gain for many women, though. Weight gain is often cited as the reason women stop using the shots. DMPA can change body composition and increase fat mass. PIP: In Chiang Mai, Thailand, community physicians followed 2422 women who used the contraceptive injectable, Depo-Provera (DMPA), either during pregnancy and/or while breast feeding. They compared the longterm growth of the children exposed to DMPA with that of 1167 children who were not exposed to hormones during pregnancy or lactation. Uses. Warnings: This medication may cause serious bone loss which may not return to normal after you stop using it. The risk of bone loss increases with longer use of this medication and smoking ... Aug 7, 2023 · signs of a blood clot - sudden numbness or weakness, severe headache, chest pain, sudden cough, coughing up blood; problems with vision or speech, swelling or pain in an arm or leg. Common Depo-Provera side effects may include: changes in your menstrual periods; weakness, feeling tired; stomach pain; feeling nervous; severe, sudden headache. shortness of breath. slurred speech. stopping of menstrual bleeding. sudden loss of coordination. sudden, severe weakness or numbness in the arm or leg. sudden, unexplained shortness of breath. swelling of the fingers, hands, feet, or lower legs. troubled breathing at rest.So I have been on depo for about two years now and have never had severe problems. I have noticed since starting Depo that I have more vaginal discharge, more acne, and my boobs tend to be sore more often. However, this past week I have noticed an intense increase in some side effects. My boobs are extremely sore and I am having a mixture of ...Oct 1, 2022 · Lifestyle Changes. Depo-Provera ( depot medroxyprogesterone acetate , or DMPA) is an effective and relatively easy form of birth control. It does appear to cause weight gain for many women, though. Weight gain is often cited as the reason women stop using the shots. DMPA can change body composition and increase fat mass. A person needs a Depo-Provera shot every 3 months to ensure it remains effective in preventing pregnancy. The birth control shot, or depo shot, Depo-Provera, or DMPA, is an injection that a person ...Limiting contraceptive options like DMPA may disproportionately affect adolescents and disadvantaged women. Depot medroxyprogesterone acetate inhibits the secretion of pituitary gonadotropins, resulting in anovulation and decreased production of estrogen. Decreased estrogen production is of concern because it is associated with a decrease in ...Spotting (light bleeding or brown discharge between periods) Not getting your period at all. About half of people stop getting their period while they’re on the shot (don’t worry, this is totally safe). Other possible side effects include: Nausea. Weight gain. Headaches. Sore breasts. Depression. .